https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43158 Wed 14 Jun 2023 09:50:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9577 Wed 11 Apr 2018 17:20:07 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11154 Wed 11 Apr 2018 15:11:56 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6941 Wed 11 Apr 2018 11:45:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7731 Wed 11 Apr 2018 11:25:30 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15157 Wed 11 Apr 2018 10:46:34 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33617 Wed 04 Sep 2019 09:39:14 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42382 Thu 08 Jun 2023 13:31:17 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55552 Thu 06 Jun 2024 10:13:50 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7347 Sat 24 Mar 2018 08:40:16 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1898 440 msec. Results: There were 469 SSRI poisoning admissions analyzed after exclusions. The median LOS for all SSRI overdose admissions was 15.3 h (IQR: 10.5–21.3) and 30 of 469 (6.4%; 95% CI 4.3–9.0%) cases were admitted to ICU. The incidence of seizures was 1.9% and coma was 2.4%. Serotonin syndrome occurred in 14% of overdoses. Comparison of median QTc intervals of the five SSRIs was significantly different (p = 0.0002); citalopram (450 IQR: 436–484) was individually different to fluoxetine (p = 0.045), fluvoxamine (p = 0.022), paroxetine (p = 0.0002), and sertraline (p = 0.001). The proportion of citalopram overdoses with a QTc > 440 msec was 68%, differing significantly from sertraline (adjusted OR: 5.11 95% CI 2.32–11.27). Comparison of median QT intervals of the five SSRIs was statistically different (p = 0.026); citalopram (400 IQR: 380–440) was individually different from sertraline (p = 0.023). Conclusions: This study shows SSRIs are relatively safe in overdose despite serotonin syndrome being common. The exception was citalopram, which was significantly associated with QTc prolongation. We believe that cardiac monitoring should be considered in citalopram overdose, particularly with large ingestions and patients with associated cardiac disease.]]> Sat 24 Mar 2018 08:33:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14357 Sat 24 Mar 2018 08:20:13 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10499 Sat 24 Mar 2018 08:09:00 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18536 Sat 24 Mar 2018 07:50:11 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5358 Sat 24 Mar 2018 07:43:57 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29325 Sat 24 Mar 2018 07:34:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39523 Mon 25 Jul 2022 15:19:59 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37875 Fri 28 May 2021 12:17:08 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13708 Fri 27 Sep 2024 14:40:10 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46576 n = 10,892, 52.8% women). We calculated country-specific prevalence of low grip strength, slow GS (≤ 0.8 m/s), and both measures combined. Using multivariable negative binomial regression, we separately assessed associations between low grip strength, slow GS, and both measures combined, with the WHO Disability Assessment Schedule 2.0, accounting for selected socioeconomic factors. In women, low grip strength ranged from 7 in South Africa to 51% in India; in men, it ranged from 17 in Russia to 51% in Mexico. Country-specific proportions of slow GS ranged from 77 in Russia, to 33% in China. The concomitant presence of both was the lowest in South Africa and the highest in India (12.3% vs. 33%). Independent of age, those with both low grip strength and slow GS had between 1.2- and 1.5-fold worse functional disability scores, independent of comorbidities, low education, and low wealth (all country-dependent). Low grip strength, slow GS, and the combination of both, were all associated with higher levels of functional disability, thus indicating these objective measures offer a reasonably robust estimate for potential poor health outcomes.]]> Fri 23 Jun 2023 12:19:34 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51506 Fri 08 Sep 2023 11:57:56 AEST ]]>